Title Journal Year Author(s) PubMed Link Research Category
The Utility of Pharmacometric Models in Clinical Pharmacology Research in Infants Current Pharmacology Reports 2020 An G* Springer Pediatric Clinical Pharmacology
Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Adults in an Open Label Phase 1 Multiple Ascending Dose and Food Effect Study Antimicrob Agents Chemother 2020 Bach T, Galbiati S, Kennedy J, Deye G, Nomicos E, Codd EE, Garcia HH, Horton J, Gilman RH, Gonzalez AE, Winokur P*, and An G* PubMed Clinical PK
Population Pharmacokinetics of Linezolid in TB Patients: Dosing Regimens Simulation and Target Attainment Analysis Antimicrob Agents Chemother 2020 Alghamdi WA, Al-Shaer MH, An G, Alsultan A, Kipiani M, Barbakadze K, Mikiashvili L, Cegielski PJ, Kempker RR, Peloquin CA PubMed Population PK
Ethionamide population pharmacokinetic model and target attainment in multidrug-resistant tuberculosis Antimicrob Agents Chemother 2020 Al-Shaer MH, Märtson AG, Alghamdi WA, Alsultan A, An G, Ahmed S, Alkabab Y, Banu S, Houpt ER, Ashkin D, Griffith DE, Cegielski JP, Heysell SK, Peloquin CA PubMed Population PK
Simultaneous Target-Mediated Drug Disposition (TMDD) Model for Two Small-Molecule Compounds Competing for Their Pharmacological Target: Soluble Epoxide Hydrolase Journal of Pharmacology and Experimental Therapeutics 2020 Wu N, Hammock BD, Lee KSS*, An G* PubMed Small-molecule compound TMDD, Population PK
Neonatal umbilical arterial catheter removal is accompanied by a marked decline in phlebotomy blood loss Neonatology 2020 Carroll PD, Zimmerman BM, Nalbant D, Gingerich EL, An G, Cress GA, Veng-Pedersen P, Widness JA PubMed Pediatric Clinical Pharmacology
Aspects of Matrix and Analyte Effects in Clinical Pharmacokinetic Sample Analyses using LC-ESI/MS/MS – Two Case Exampless J Pharm Biomed Anal 2020 An G*, Bach T, Abdallah I, Nalbant D PubMed Bioanalysis, Clinical PK
Concept of Pharmacologic Target-Mediated Drug Disposition (TMDD) in Large-Molecule and Small-Molecule Compounds Journal of Clinical Pharmacology 2020 An G* PubMed Small-molecule compound TMDD
Target-Mediated Disposition Population Pharmacokinetics Model of Erythropoietin in Premature Neonates Following Multiple Dosing Regimens European Journal of Pharmaceutical Sciences 2019 D’Cunha R, Schmidt R, Widness JA, Mock DM, Yan X, Cress GA, Kuruvilla D, Veng-Pedersen P, An G* PubMed Pediatric Clinical Pharmacology, Population PK
Nilotinib alters the efflux transporter-mediated pharmacokinetics of afatinib in mice Journal of Pharmaceutical Sciences 2019 D'Cunha R, Murry DJ, An G* PubMed Preclinical PK, Drug Transporter
Fluoroquinolones in drug-resistant tuberculosis: culture conversion and pharmacokinetic/pharmacodynamic target attainment to guide dose selection Antimicrob Agents Chemother 2019 Al-Shaer MH, Alghamdi WA, Alsultan A, An G, Ahmed S, Alkabab Y, Banu S, Barbakadze K, Houpt E, Kipiani M, Mikiashvili L, Cegielski JP, Kempker RR, Heysell SK, Peloquin CA PubMed Population PK/PD
Development and validation of a simple, fast, and sensitive LC/MS/MS method for the quantification of oxfendazole in human plasma and its application to clinical pharmacokinetic study J Pharm Biomed Anal 2019 Bach T, Bae S, D'Cunha R, Winokur P, An G* PubMed Bioanalysis
Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis Antimicrob Agents Chemother 2019 Alghamdi, WA, Alsultan, A, Al-Shaer, MH, An G, Ahmed S, Alkabab Y, Banu S, Barbakadze K, Houpt E, Kipiani M, Mikiashvili L, Schmidt S, Heysell SK, Kempker RR, Cegielski P, Peloquin CA PubMed Population PK/PD
Pharmacokinetics, Safety, and Tolerability of Oxfendazole in Healthy Volunteers: a Randomized, Placebo-Controlled First-in-Human Single-Dose Escalation Study Antimicrob Agents Chemother 2019 An G*, Murry DJ, Gajurel K, Bach T, Deye G, Stebounova LV, Codd EE, Horton J, Gonzalez AE, Garcia HH, Ince D, Hodgson-Zingman D, Nomicos EYH, Conrad T, Kennedy J, Jones W, Gilman RH, Winokur P* PubMed Clinical PK
A Mechanism-Based Population Pharmacokinetics Model of Erythropoietin in Premature Infants and Healthy Adults Following Multiple Intravenous Doses Journal of Clinical Pharmacology 2019 D’Cunha R, Widness JA, Yan X, Schmidt R, Veng-Pedersen P, An G* PubMed Pediatric Clinical Pharmacology, Population PK
General Pharmacokinetic Features of Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Simulation-Based Study J Clin Pharmacol 2019 Bach T, Jiang Y, Zhang X, An G* PubMed Small-molecule compound TMDD
Association between metabolic profiles in urine and bone mineral density of pre- and postmenopausal Chinese women Menopause 2019 Yu L, Qi H, An G, Bao J, Ma B, Zhu J, Ouyang G, Zhang P, Fan H, Zhang Q PubMed Metabolomics
Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs-a Case Example of Erythropoietin The AAPS Journal 2018 An G*, Schmidt RL, Mock DM, Veng-Pedersen P, Widness JA PubMed Clinical PK
Quantification of Cefepime, Meropenem, Piperacillin and Tazobactam in Human Plasma using a Sensitive and Robust LC-MS/MS Method- Part I. Assay Development and Validation Antimicrob Agents Chemother 2018 D'Cunha R, Bach T, Young BA, Li P, Nalbant D, Zhang J, Winokur P, An G* PubMed Bioanalysis
Quantification of Cefepime, Meropenem, Piperacillin and Tazobactam in Human Plasma using a Sensitive and Robust LC-MS/MS Method- Part II. Stability Evaluation Antimicrob Agents Chemother 2018 D'Cunha R, Bach T, Young BA, Li P, Nalbant D, Zhang J, Winokur P, An G* PubMed Bioanalysis
Beta-lactam carryover in arterial and central venous catheters is negligible Clin Chim Acta 2018 Marsh E, Verhoven SM, Groszek JJ, Fissell WH, An G, Patel P, Creech B, Shotwell M PubMed Bioanalysis
Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations Transfusion 2018 Mock DM, Nalbant D, Kyosseva SV, Schmidt RL, An G, Matthews NI, Vlaar APJ, van Bruggen R, de Korte D, Strauss RG, Cancelas JA, Franco RS, Veng-Pedersen P, Widness JA PubMed Category
Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice European Journal of Pharmaceutical Sciences 2018 Bae S, D'Cunha R, Shao J, An G* PubMed Preclinical PK, Drug Transporter
Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response Acta Pharmacologica Sinica 2018 Wang Y, Guo SH, Shang XJ, Yu LS, Zhu JW, Zhao A, Zhou YF, An G, Zhang Q, Ma B PubMed Category
Relating Observed Psychoactive Effects to the Plasma Concentrations of Delta-9-Tetrahydrocannabinol and Its Active Metabolite: An Effect-Compartment Modeling Approach Journal of Pharmaceutical Sciences 2018 Awasthi R, An G, Donovan MD, Boles Ponto LL PubMed Population PK
Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing Journal of Pharmaceutical Sciences 2017 An G*, Ohls RK, Christensen RD, Widness JA, Mock DM, Veng-Pedersen P PubMed Pediatric Clinical Pharmacology, Population PK
A Mechanism-based Pharmacokinetic Enzyme Turnover Model for Dichloroacetic Acid Auto-Inhibition in Rats Journal of Pharmaceutical Sciences 2017 Jiang Y, Milavetz G, James MO, An G* PubMed Population PK
Metabonomic analysis of fatty acids in seminal plasma between healthy and asthenozoospermic men based on gas chromatography mass spectrometry Andrologia 2017 Tang B, Shang X, Qi H, Li J, Ma B, An G, and Zhang Q PubMed Metabolomics
Estimation of Adult and Neonatal RBC Lifespans in Anemic Neonates using RBCs Labeled at Several Discrete Biotin Densities Pediatric Research 2017 Kuruvilla D, Widness JA, Nalbant D, Schmidt RL, Mock DM, An G, and Veng-Pedersen P PubMed Pediatric Clinical Pharmacology
Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Minireview Journal of Clinical Pharmacology 2017 An G* PubMed Small-molecule compound TMDD
TKI combination therapy: strategy to enhance dasatinib uptake by inhibiting Pgp- and BCRP-mediated efflux Biopharmaceutics & Drug Disposition 2016 D'Cunha R, Bae S, Murry DJ, An G* PubMed Drug Transporter
A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups The AAPS Journal 2016 An G*, Widness JA, Mock DM, Veng-Pedersen P PubMed Mathematical Modeling
Association between the metabolome and bone mineral density in pre- and post-menopausal Chinese women using GC-MS Molecular Biosystems 2016 Qi H, Bao J, An G, Ouyang G, Zhang P, Wang C, Ying H, Ouyang P, Ma B, Zhang Q PubMed Metabolomics
A Whole-Body Physiologically Based Pharmacokinetic Model of Gefitinib in Mice and Scale-Up to Humans The AAPS Journal 2016 Bi Y, Deng J, Murry DJ, An G* PubMed Whole-body PBPK modeling
Pharmacokinetics and tissue distribution of 5,7-dimethoxyflavone in mice following single dose oral administration Journal of Pharmaceutical and Biomedical Analysis 2016 Bei D and An G* PubMed Preclinical PK
Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC-MS based metabolomics study Toxicology 2015 Ma B, Qi H, Li J, Xu H, Chi B, Zhu J, Yu L, An G, Zhang Q PubMed Metabolomics
Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea Journal of Clinical Pharmacology 2015 An G*, Kaur Mukker J, Derendorf H, Frye RF PubMed Drug Transporter
A Randomized Double-blind, Placebo- and Active-Controlled Study of T-Type Calcium Channel Blocker ABT-639 in Patients with Diabetic Peripheral Neuropathic Pain Pain 2015 Ziegler D, Duan R, An G, Thomas JW, and Nothaft W PubMed Clinical Trial
Reply: Clinical experience with fondaparinux in critically ill patients with moderate to severe renal impairment and renal failure requiring renal replacement therapy Annals of Pharmacotherapy 2015 Cope J, Bushwitz J, An G, Antigua A, Patel A, and Zumberg M PubMed
Limited Sampling Strategy and Target Attainment Analysis for Levofloxacin in Patients with Tuberculosis Antimicrobial Agents & Chemotherapy 2015 Alsultan A, An G, and Peloquin CA PubMed Population PK/PD
Small Molecule Compounds Exhibiting Target Mediated Drug Disposition (TMDD) – a Case Example of ABT-384 Journal of Clinical Pharmacology 2015 An G*, Liu W, and Dutta S PubMed Small-molecule compound TMDD
Clinical experience with fondaparinux in critically ill patients with moderate to severe renal impairment and renal failure requiring renal replacement therapy Annals of Pharmacotherapy 2015 Cope J, Bushwitz J, An G, Antigua A, Patel A, and Zumberg M. PubMed Population PK
Population Pharmacokinetics and Exposure-Uric Acid Analyses after Single and Multiple Doses of ABT-639, a Calcium Channel Blocker, in Healthy Volunteers The AAPS Journal 2015 An G*, Liu W, Duan R, Nothaft W, Awni W, and Dutta S PubMed Population PK/PD
Ingredients in Fruit Juice Interact with Dasatinib through Inhibition of BCRP: A New Mechanism of Beverage-Drug Interaction Journal of Pharmaceutical Sciences 2015 Fleisher B, Uum J, Shao J, and An G* PubMed Drug Transporter
Quantification of 5,7-Dimethoxyflavone in Mouse Plasma using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) and its Application to a Pharmacokinetic Study Journal of Chromatography B 2015 Bei D and An G* PubMed Bioanalysis
Population Pharmacokinetics of Rifampin in the Treatment of Mycobacterium Tuberculosis in Elephants Journal of Veterinary Pharmacology and Therapeutics 2015 Egelund EF, Isaza R, Brock AP, Alsultan A, An G, and Peloquin CA PubMed Population PK
Enzyme- and Transporter-Mediated Drug Interactions with Small Molecule Tyrosine Kinase Inhibitors Journal of Pharmaceutical Sciences 2014 Shao J, Markowitz JS, Bei D, and An G* PubMed Drug Transporter
Population Pharmacokinetics of the 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers following Single and Multiple Dose Regimens Biopharmaceutics & Drug Disposition 2014 An G*, Liu W, Katz D, Marek G, Awni W, and Dutta S PubMed Population PK, Small-molecule compound TMDD
Dietary Flavonoids are Inhibitors of Human Organic Anion Transporter 1 (OAT1) Drug Metabolism and Disposition 2014 An G, Wang X, and Morris ME PubMed Drug Transporter
ABC Transporters in the Multi-drug Resistance and ADME-Tox of Small Molecule Tyrosine Kinase Inhibitors Pharmaceutical Research 2014 Deng J, Shao J, Markowitz JS, and An G* PubMed Drug Transporter
Peripheral and central nervous system inhibition of 11ß-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384 Translational Psychiatry 2013 Katz DA, Liu W, Locke C, Jacobson P, Barnes DM, Basu R, An G, Rieser MJ, Daszkowski D, Groves F, Heneghan G, Shah A, Gevorkyan H, Jhee SS, Ereshefsky L, Marek GJ PubMed Clinical Trial
Effect of Ketoconazole on the Pharmacokinetics of ABT-384 and Its Two Active Metabolites in Healthy Volunteers: Population Analysis of Data from a Drug-Drug Interaction Study Drug Metabolism and Disposition 2013 An G*, Liu W, Katz D, Marek G, Awni W, and Dutta S PubMed Population PK
A physiologically based pharmacokinetic model of mitoxantrone in mice and scale-up to humans: a semi-mechanistic model incorporating DNA and protein binding The AAPS Journal 2012 An G and Morris ME PubMed Whole-body PBPK modeling
Optimal Parameters of HPLC for Simultaneous Determination Robinin and Kaempferol Pharmaceutical Chemistry Journal 2012 Tsiklauri L, An G, Alaniya M, Kemertelidze E, Morris ME N/A Bioanalysis
The sulfated conjugate of biochanin A is a substrate of breast cancer resistant protein (ABCG2) Biopharmaceutics & Drug Disposition 2011 An G and Morris ME PubMed Drug Transporter
5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice Pharmaceutical Research 2011 An G, Wu F, and Morris ME PubMed Preclinical PK, Drug Transporter
The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux Drug Metabolism & Disposition 2011 An G, Gallegos J, and Morris ME PubMed Drug Transporter
Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry Journal of Pharmaceutical and Biomedical Analysis 2011 Tsiklauri L, An G, Ruszaj DM, Alaniya M, Kemertelidze E, Morris ME PubMed Bioanalysis
Effects of single and multiple flavonoids on BCRP-mediated accumulation, cytotoxicity and transport of mitoxantrone in vitro Pharmaceutical Research 2010 An G and Morris ME PubMed Drug Transporter
Interference of a sulfate conjugate in quantitative liquid chromatography/tandem mass spectrometry through in-source dissociation Rapid Communications in Mass Spectrometry 2010 An G, Ruszaj DM, and Morris ME PubMed Bioanalysis
The effect of isoflavonoid biochanin A on the transport of mitoxantrone in vitro and in vivo Biopharmaceutics & Drug Disposition 2010 An G and Morris ME PubMed Preclinical PK, Drug Transporter
HPLC analysis of mitoxantrone in mouse plasma and tissues: Application in a pharmacokinetic study J Pharm Biomed Anal 2010 An G and Morris ME PubMed Bioanalysis
Biochanin A inhibits breast cancer tumor growth in a murine xenograft model Pharmaceutical Research 2008 Moon YJ, Shin BS, An G and Morris ME PubMed Preclinical PD
Relative bioavailability and bioequivalence of ibuprofen orally disintegrating tablets in healthy volunteers Chinese Journal of Clinical Pharmacy 2006 Yu Z, Chen B, Zhang W, Fang J, An G and Cai WM N/A Clinical PK
Limited sampling strategy for the estimation of mycophenolic acid area under the plasma concentration-time curve in adult Chinese renal recipients Chinese Journal of Clinical Pharmacology 2006 Yu Z, Zhou P, Wang X, Xu D, Chen B, Zhang W, An G and Fang J N/A Clinical PK
Pharmacokinetics of Pazufloxacin Mesilate in Chinese Healthy Volunteers Chinese Pharmaceutical Journal 2006 Yu Z, Chen B, Zhang W, An G, Fang J, and Cai WM N/A Clinical PK
The application status and future trend of parenteral nutrition preparation China Pharmacy 2005 Di Q, Zhu B, An G, and Cai WM N/A Hospital Pharmacy
The cost-effective analysis of different antihyperglycemic therapies in patients with type 2 diabetes mellitus Chinese Journal of Hospital Pharmacy J 2004 An G, Ji MC, Geng XF, and Cheng NN N/A Category
Interactions of antihyperglycemic agents and drugs Chinese Journal of Clinical Pharmacology 2003 An G, Geng XF, and Ji MC N/A Category
Prescribing patterns and therapeutic implications in a cohort of 200 outpatients with type 2 diabetes and hypertension Chinese Journal of Pharmacoepidemiology 2003 An G, Geng XF, and Ji MC N/A Category
The rational drug use analysis in insomniac patients in comprehensive hospital Chinese Academic Medical Magazine of Organisms 2002 Ji MC, Geng XF, and An G N/A Category
The application of evidence-based medicine in the drug therapy of type 2 Diabetes Mellitus Chinese Academic Medical Magazine of Organisms 2002 An G, Geng XF, and Ji MC N/A Category